Reds striker Michael Chopra and midfielder Antony Kay are back after suspensions but centre-half Paul Reid (foot) is still injured.
Kay is likely to partner Bobby Hassell in the centre of defence.
Defender Neil Austin has recovered from a hamstring injury so is likely to return to the bench after playing for the reserves in midweek.
Luton's news signing Warren Feeney will not be available as he is on international duty with Northern Ireland who play England on Saturday.